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1

Don't worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression

John F. Cryan, Klemens Kaupmann

Journal:

Trends in Pharmacological Sciences

Year:

2005

Language:

english

File:

PDF, 1.04 MB

english, 2005

2

Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model

Carcache, David, Vulpetti, Anna, Kallen, Joerg, Mattes, Henri, Orain, David, Stringer, Rowan, Vangrevelinghe, Eric, Wolf, Romain M, Kaupmann, Klemens, Ottl, Johannes, Dawson King, Janet, Cooke, Nigel

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.88 MB

english, 2018

3

Spatial distribution of GABABR1 receptor mRNA and binding sites in the rat brain

Bischoff, Serge, Leonhard, Sabine, Reymann, Nicole, Schuler, Val�rie, Shigemoto, Ryuichi, Kaupmann, Klemens, Bettler, Bernhard

Journal:

The Journal of Comparative Neurology

Year:

1999

Language:

english

File:

PDF, 2.35 MB

english, 1999

4

Independent maturation of the GABAB receptor subunits GABAB1 and GABAB2 during postnatal development in rodent brain

Jean-Marc Fritschy, Corinne Sidler, Franziska Parpan, Martin Gassmann, Klemens Kaupmann, Bernhard Bettler, Dietmar Benke

Journal:

The Journal of Comparative Neurology

Year:

2004

Language:

english

File:

PDF, 2.53 MB

english, 2004

5

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABAB receptors

Sébastien Guery, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

6

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor

Samuel Hintermann, Konstanze Hurth, Joachim Nozulak, Marina Tintelnot-Blomley, Reiner Aichholz, Joachim Blanz, Klemens Kaupmann, Johannes Mosbacher

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 493 KB

english, 2011

7

Alternative splicing generates a novel isoform of the rat metabotropic GABABR1 receptor

Torsten Pfaff, Barbara Malitschek, Klemens Kaupmann, Laurent Prézeau, Jean-Philippe Pin, Bernhard Bettler, Andreas Karschin

Journal:

European Journal of Neuroscience

Year:

1999

Language:

english

File:

PDF, 472 KB

english, 1999

8

The mouse homolog to theras-related yeast geneYPT1maps on Chromosome 11 close to the wobbler (wr) locus

Hendrik Wichmann, Harald Jockusch, Jean Louis Guénet, Dieter Gallwitz, Klemens Kaupmann

Journal:

Mammalian Genome

Year:

1992

Language:

english

File:

PDF, 179 KB

english, 1992

9

Behavioral evaluation of mice deficient in GABAB(1)receptor isoforms in tests of unconditioned anxiety

Laura H. Jacobson, Bernhard Bettler, Klemens Kaupmann, John F. Cryan

Journal:

Psychopharmacology

Year:

2007

Language:

english

File:

PDF, 465 KB

english, 2007

10

Roles of GABABreceptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release

Peter C. Waldmeier, Klemens Kaupmann, Stephan Urwyler

Journal:

Journal of Neural Transmission

Year:

2008

Language:

english

File:

PDF, 430 KB

english, 2008

11

Roles of GABABreceptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release

Peter C. Waldmeier, Klemens Kaupmann, Stephan Urwyler

Journal:

Journal of Neural Transmission

Year:

2009

Language:

english

File:

PDF, 128 KB

english, 2009

12

Mapping, genomic structure, and polymorphisms of the humanGABABR1receptor gene: evaluation of its involvement in idiopathic generalized epilepsy

Howard Christian Peters, Gudrun Kämmer, Armin Volz, Klemens Kaupmann, Andreas Ziegler, Bernhard Bettler, Jörg T. Epplen, Thomas Sander, O. Riess

Journal:

Year:

1998

Language:

english

File:

PDF, 174 KB

english, 1998

13

The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease ‘Wobbler’ of the Mouse

Klemens Kaupmann, Michael Sendtner, Kurt A. Stöckli, Harald Jockusch

Journal:

European Journal of Neuroscience

Year:

1991

Language:

english

File:

PDF, 519 KB

english, 1991

14

Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice

Claire-Marie Vacher, Martin Gassmann, Sandrine Desrayaud, Etienne Challet, Amyaouch Bradaia, Daniel Hoyer, Peter Waldmeier, Klemens Kaupmann, Paul Pévet, Bernhard Bettler

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 718 KB

english, 2006

15

Heteromerization of GABAB Receptors: A New Principle for G Protein-Coupled Receptors. Satellite Symposium to the 28th Annual Meeting of the Society for Neuroscience Los Angeles, CA, November 5–7, 1998

Klemens Kaupmann, Bernard Bettler

Journal:

CNS Drug Reviews

Year:

1998

Language:

english

File:

PDF, 78 KB

english, 1998

16

Reduction of Alcohol’s Reinforcing and Motivational Properties by the Positive Allosteric Modulator of the GABAB Receptor, BHF177, in Alcohol-Preferring Rats

Paola Maccioni, Mauro A.M. Carai, Klemens Kaupmann, Sébastien Guery, Wolfgang Froestl, Kimberly A. Leite-Morris, Gian Luigi Gessa, Giancarlo Colombo

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2009

Language:

english

File:

PDF, 576 KB

english, 2009

17

10.1038/25360

Bettler, Bernhard, Kaupmann, Klemens, Malitschek, Barbara, Schuler, Valerie, Heid, Jakob, Froestl, Wolfgang, Beck, Pascal, Mosbacher, Johannes, Bischoff, Serge, Kulik, Akos, Shigemoto, Ryuichi, Karsch

Journal:

Year:

1998

Language:

english

File:

PDF, 2.29 MB

english, 1998

18

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

Kaupmann, Klemens, Huggel, Katharina, Heid, Jakob, Flor, Peter J., Bischoff, Serge, Mickel, Stuart J., McMaster, Gary, Angst, Christof, Bittiger, Helmut, Froestl, Wolfgang

Journal:

Year:

1997

File:

PDF, 2.17 MB

1997

19

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition

Shaban, Hamdy, Humeau, Yann, Herry, Cyril, Cassasus, Guillaume, Shigemoto, Ryuichi, Ciocchi, Stephane, Barbieri, Samuel, van der Putten, Herman, Kaupmann, Klemens, Bettler, Bernhard

Journal:

Nature Neuroscience

Year:

2006

Language:

english

File:

PDF, 499 KB

english, 2006

20

Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice

Klemens Kaupmann, John F. Cryan, Petrine Wellendorph, Cedric Mombereau, Gilles Sansig, Klaus Klebs, Markus Schmutz, Wolfgang Froestl, Herman Van Der Putten, Johannes Mosbacher, Hans Bräuner-Osborne, P

Journal:

European Journal of Neuroscience

Year:

2003

Language:

english

File:

PDF, 443 KB

english, 2003

21

Altered hippocampal expression of calbindin-D-28k and calretinin in GABAB(1)-deficient mice

Elisabeth Rüttimann, Claire-Marie Vacher, Martin Gassmann, Klemens Kaupmann, Herman Van der Putten, Bernhard Bettler

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 646 KB

english, 2004

22

GABAB receptor positive modulators: Effects on nicotine self-administration and cue-induced reinstatement of nicotine-seeking behavior in rats

Styliani Vlachou, Sébastien Guery, Wolfgang Froestl, Klemens Kaupmann, Deboshri Banerjee, M.G. Finn, Athina Markou

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 72 KB

english, 2009

23

Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors

Stephan Urwyler, Tina Gjoni, Klemens Kaupmann, Mario F. Pozza, Johannes Mosbacher

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 442 KB

english, 2004

24

Altered response to benzodiazepine anxiolytics in mice lacking GABAB(1) receptors

Cedric Mombereau, Klemens Kaupmann, Herman van der Putten, John F. Cryan

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 81 KB

english, 2004

25

Both GABAB receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats

Styliani Vlachou, Neil E. Paterson, Sebastien Guery, Klemens Kaupmann, Wolfgang Froestl, Deboshri Banerjee, M.G. Finn, Athina Markou

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 440 KB

english, 2011

26

Ligands for expression cloning and isolation of GABAB receptors

Wolfgang Froestl, Bernhard Bettler, Helmut Bittiger, Jakob Heid, Klemens Kaupmann, Stuart J. Mickel, Dietrich Strub

Journal:

Year:

2001

Language:

english

File:

PDF, 134 KB

english, 2001

27

Ligands for expression cloning and isolation of GABAB receptors

Wolfgang Froestl, Bernhard Bettler, Helmut Bittiger, Jakob Heid, Klemens Kaupmann, Stuart J. Mickel, Dietrich Strub

Journal:

Year:

2003

Language:

english

File:

PDF, 421 KB

english, 2003

28

Chromosomal Localization and Genomic Cloning of the Mouse α-Tropomyosin Gene Tpm-1

Martin Schleef, Katharina Werner, Ulla Satzger, Klemens Kaupmann, Harald Jockusch

Journal:

Year:

1993

File:

PDF, 194 KB

1993

29

Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain

Klemens Kaupmann, Christian Bruns, Daniel Hoyer, Klaus Seuwen, Hermann Lübbert

Journal:

Year:

1993

Language:

english

File:

PDF, 821 KB

english, 1993

30

Specific roles of GABAB(1) receptor isoforms in cognition

Laura H. Jacobson, Peter H. Kelly, Bernhard Bettler, Klemens Kaupmann, John F. Cryan

Journal:

Behavioural Brain Research

Year:

2007

Language:

english

File:

PDF, 232 KB

english, 2007

31

The heteromeric GABA-B receptor recognizes G-protein α subunit C-termini

Miloslav Franek, Adriana Pagano, Klemens Kaupmann, Bernhard Bettler, Jean-Philippe Pin, Jaroslav Blahos

Journal:

Neuropharmacology

Year:

1999

Language:

english

File:

PDF, 306 KB

english, 1999

32

γ-Hydroxybutyrate is a weak agonist at recombinant GABAB receptors

Kurt Lingenhoehl, Richard Brom, Jakob Heid, Pascal Beck, Wolfgang Froestl, Klemens Kaupmann, Bernhard Bettler, Johannes Mosbacher

Journal:

Neuropharmacology

Year:

1999

Language:

english

File:

PDF, 232 KB

english, 1999

33

Ligands for the isolation of GABAB receptors: W. Froestl would like to dedicate this work to the first GABAB chemist, Cr Heinrich Keberle, on the occasion of his 77th birthday.

Wolfgang Froestl, Bernhard Bettler, Helmut Bittiger, Jakob Heid, Klemens Kaupmann, Stuart J. Mickel, Dietrich Strub

Journal:

Neuropharmacology

Year:

1999

Language:

english

File:

PDF, 118 KB

english, 1999

34

Erratum to “Ligands for the isolation of GABAB receptors”: [Neuropharmacology 38 (1999), 1641–1646]

Wolfgang Froestl, Bernhard Bettler, Helmut Bittiger, Jakob Heid, Klemens Kaupmann, Stuart J Mickel, Dietrich Strub

Journal:

Neuropharmacology

Year:

1999

Language:

english

File:

PDF, 28 KB

english, 1999

35

GABAB receptors – the first 7TM heterodimers

Fiona H Marshall, Kenneth A Jones, Klemens Kaupmann, Bernhard Bettler

Journal:

Trends in Pharmacological Sciences

Year:

1999

Language:

english

File:

PDF, 311 KB

english, 1999

36

GABAB receptors: drugs meet clones

Bernhard Bettler, Klemens Kaupmann, Norman Bowery

Journal:

Current Opinion in Neurobiology

Year:

1998

Language:

english

File:

PDF, 749 KB

english, 1998

37

Recognition molecule associated carbohydrate inhibits postsynaptic GABAB receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses

Armen K Saghatelyan, Marina Snapyan, Silke Gorissen, Inge Meigel, Johannes Mosbacher, Klemens Kaupmann, Bernhard Bettler, Andrei V Kornilov, Nikolay E Nifantiev, Vehary Sakanyan, Melitta Schachner, Al

Journal:

Molecular and Cellular Neuroscience

Year:

2003

Language:

english

File:

PDF, 500 KB

english, 2003

38

Developmental Changes of Agonist Affinity at GABABR1 Receptor Variants in Rat Brain

Barbara Malitschek, Doris Rüegg, Jakob Heid, Klemens Kaupmann, Helmut Bittiger, Wolfgang Fröstl, Bernhard Bettler, Rainer Kuhn

Journal:

Molecular and Cellular Neuroscience

Year:

1998

Language:

english

File:

PDF, 250 KB

english, 1998

39

Molecular Pharmacology of Somatostatin-receptor Subtypes

CHRISTIAN BRUNS, GISBERT WECKBECKER, FRIEDRICH RAULF, KLEMENS KAUPMANN, PHILIPPE SCHOEFFTER, DANIEL HOYER, HERMANN LÜBBERT

Journal:

Annals of the New York Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 441 KB

english, 1994

40

Exploring the mammalian neuromuscular system by analysis of mutations: Spinal muscular atrophy and myotonia

Jockusch, Harald, Kaupmann, Klemens, Gronemeier, Monika, Schleef, Martin, Klocke, Rainer

Journal:

Progress in Neurobiology

Year:

1994

Language:

english

File:

PDF, 434 KB

english, 1994

41

The gene for the cell adhesion molecule m-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the e-cadherin (uvomorulin) locus in both species

Kaupmann, Klemens, Becker-Follmann, Johannes, Scherer, Gerd, Jockusch, Harald, Starzinski-Powitz, Anna

Journal:

Year:

1992

Language:

english

File:

PDF, 544 KB

english, 1992

42

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11

Kaupmann, Klemens, Simon-Chazottes, Dominique, Guénet, Jean-Louis, Jockusch, Harald

Journal:

Year:

1992

Language:

english

File:

PDF, 948 KB

english, 1992

43

Human γ -aminobutyric Acid Type B Receptors are Differentially Expressed and Regulate Inwardly Rectifying K+Channels

Klemens Kaupmann, Valerie Schuler, Johannes Mosbacher, Serge Bischoff, Helmut Bittiger, Jakob Heid, Wolfgang Froestl, Sabine Leonhard, Torsten Pfaff, Andreas Karschin and Bernhard Bettler

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.91 MB

english, 1998

44

Encyclopedia of Life Sciences || GABA B Receptors

Kaupmann, Klemens

Year:

2001

Language:

english

File:

PDF, 618 KB

english, 2001

45

GABAB Receptor-Positive Modulation Decreases Selective Molecular and Behavioral Effects of Cocaine

Lhuillier, Loic, Mombereau, Cedric, Cryan, John F, Kaupmann, Klemens

Journal:

Neuropsychopharmacology

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

46

Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior

Mombereau, Cedric, Kaupmann, Klemens, Froestl, Wolfgang, Sansig, Gilles, van der Putten, Herman, Cryan, John F

Journal:

Neuropsychopharmacology

Year:

2004

Language:

english

File:

PDF, 196 KB

english, 2004

47

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits

Mombereau, Cedric, Kaupmann, Klemens, Gassmann, Martin, Bettler, Bernhard, van der Putten, Herman, Cryan, John F.

Journal:

Year:

2005

Language:

english

File:

PDF, 89 KB

english, 2005

48

Determination of the minimal functional ligand-binding domain of the GABA B(1b) receptor

DERIU, Daniela, GASSMANN, Martin, FIRBANK, Susan, RISTIG, Dorothee, LAMPERT, Christina, MOSBACHER, Johannes, FROESTL, Wolfgang, KAUPMANN, Klemens, BETTLER, Bernhard, GRÜTTER, Markus G.

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 635 KB

english, 2005

49

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists

Hintermann, Samuel, Guntermann, Christine, Mattes, Henri, Carcache, David A., Wagner, Juergen, Vulpetti, Anna, Billich, Andreas, Dawson, Janet, Kaupmann, Klemens, Kallen, Joerg, Stringer, Rowan, Orain

Journal:

Year:

2016

Language:

english

File:

PDF, 974 KB

english, 2016

50

Blunted 5-HT1Areceptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1abut not GABAB1bsubunit isoforms

Jacobson, Laura H., Hoyer, Daniel, Fehlmann, Dominique, Bettler, Bernhard, Kaupmann, Klemens, Cryan, John F.

Journal:

Psychopharmacology

Year:

2017

Language:

english

File:

PDF, 2.86 MB

english, 2017